Journal
ORGANIC LETTERS
Volume 13, Issue 9, Pages 2290-2293Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol200550y
Keywords
-
Categories
Funding
- National Science Foundation of China [20872043, 21072069, 21002036]
- National Basic Research Program of China [2011CB808600]
- Program for Changjiang Scholars and Inovation Research Team in University [IRT0953]
Ask authors/readers for more resources
An asymmetric nucleophilic addition/protonation reaction of 3-substituted oxindoles and ethyl 2-phthalimidoacrylate has been described. This strategy can give direct access to C-gamma-tetrasubstituted alpha-amino acid derivatives bearing 1,3-nonadjacent stereocenters with up to 98% yield, 94:6 dr, and > 99% ee. Dual activation is proposed in the transition state, and the opposite enantiomers can be obtained simply by changing cinchonidine-derived catalyst to the cinchonine analogue.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available