Journal
ORGANIC LETTERS
Volume 13, Issue 10, Pages 2536-2539Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol200570u
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Funding
- Camille and Henry Dreyfus Foundation
- Georgia Institute of Technology
- GAANN predoctoral fellowship
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The indanomycin biosynthetic gene (idm) cluster was recently identified from Streptomyces antibioticus NRRL 8167. The disruption of one of these genes, idmH, and the increased production of a previously unreported metabolite In this mutant Is reported. The structure of this compound was elucidated and was shown to possess a linear tetraene. This metabolite is not a logical biosynthetic intermediate of indanomycin but instead Is likely an alternate product of the pathway.
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