4.8 Article

Lewis Acid-Mediated Michaelis-Arbuzov Reaction at Room Temperature: A Facile Preparation of Arylmethyl/Heteroarylmethyl Phosphonates

Journal

ORGANIC LETTERS
Volume 13, Issue 6, Pages 1270-1273

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol1029436

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Funding

  1. Department of Science and Technology (DST), New Delhi
  2. CSIR, New Delhi

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A facile preparation of arylmethyl and heteroarylmethyl phosphonate esters was achieved involving a Lewis acid mediated Michaelis-Arbuzov reaction at room temperature. Interaction of arylmethyl halides/alcohols with triethyl phosphite in the presence of Lewis acid at room temperature afforded phosphonate esters in good yields.

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