Journal
ORGANIC LETTERS
Volume 14, Issue 1, Pages 134-137Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol202931e
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Funding
- East China University of Science Technology
- China 111 Project [B07023]
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An efficient bifunctional cinchona alkaloid derived thiourea-promoted enantioselective conjugate addition of nitroalkanes to indolylidenecyanoacetates has been developed under neat conditions. The process leads to synthetically interesting densely functionalized 3,3'-disubstituted oxindoles with creation of up to three stereogenic centers.
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