4.8 Article

Rhenium-Catalyzed Regiodivergent Addition of Indoles to Terminal Alkynes

Journal

ORGANIC LETTERS
Volume 14, Issue 2, Pages 588-591

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol203199m

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Funding

  1. National Science Foundation of China [21002103]
  2. Institute of Chemistry, CAS

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An efficient rhenium-catalyzed site-switchable addition of indoles to terminal alkynes is described. A variety of bisindolylalkane derivatives are expeditiously synthesized in high yields with excellent regioselectivity. Preliminary mechanistic study sheds light on the observed regiodivergent addition.

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