4.8 Article

The N-Aryl Aminocarbonyl ortho-Substituent Effect in Cu-Catalyzed Aryl Amination and Its Application in the Synthesis of 5-Substituted 11-Oxo-dibenzodiazepines

Journal

ORGANIC LETTERS
Volume 13, Issue 24, Pages 6422-6425

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol202721h

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Funding

  1. Ministry of Science and Technology [2009ZX09501-00]
  2. Chinese Academy of Sciences
  3. National Natural Science Foundation of China [20632050, 20921091]

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Double amination of ortho-substituted aryl bromides proceeded under mild conditions to afford 5-substituted 11-oxo-dibenzodiazepines, which revealed that there is a strong ortho-substituent effect caused by N-aryl aminocarbonyl groups during copper-catalyzed aryl amination.

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