4.8 Article

Substituent Control over Dimerization Affinity of Triply Hydrogen Bonded Heterodimers

Journal

ORGANIC LETTERS
Volume 13, Issue 2, Pages 240-243

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol102619u

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Funding

  1. Leverhulme Trust [F/00122/AN]
  2. EPSRC [EP/C007638/1]
  3. Engineering and Physical Sciences Research Council [EP/C007638/1] Funding Source: researchfish

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Linear arrays of hydrogen bonds represent important elements of the supramolecular toolkit for receptor design, assembly of supramolecular polymers, and other well-defined supramolecular structures. It is illustrated that remote substituent effects control dimerization affinity in a predictable manner using a conformer independent ureidoimidazole DDA motif and its amidoisocytosine based AAD partner.

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