Journal
ORGANIC LETTERS
Volume 13, Issue 8, Pages 2054-2057Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol200456y
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Funding
- National Institutes of Health [NIH GM-082935]
- National Science Foundation [NSF-0847108]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0847108] Funding Source: National Science Foundation
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A new method to synthesize chiral alpha-amino phosphine oxides is reported. The reaction combines N-substituted imines and diphenylphosphine oxide and is catalyzed by a chiral magnesium phosphate salt. A wide variety of aliphatic and aromatic aldimines substituted by electron-neutral benzhydryl or dibenzocycloheptene groups were excellent substrates for the addition reaction. The dibenzocycloheptene protected imines afforded improved enantioselectivity in the resulting products. Substituted diphenylphosphine oxide nucleophiles also showed good reactivity.
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