Journal
ORGANIC LETTERS
Volume 13, Issue 13, Pages 3502-3505Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol201313q
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Funding
- Volkswagen Foundation [I/81 615]
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Asx-Pro-turns have been identified with high frequency in protein structures nucleating type I beta-turns. By bridging the amino acid side chain in position i with a nitrogen substituent in position i+2 by ring-closing olefin metathesis (RCM), peptide mimetics of type 1 could be developed. NMR based conformational investigations indicated a stable intramolecular H-bond constraining a U-turn conformation that was predicted to simulate a type I beta-turn.
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