Journal
ORGANIC LETTERS
Volume 12, Issue 4, Pages 716-719Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol902751x
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Funding
- National Institutes of Health [GM086258, U54AI057141]
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Bacterial acyl-homoserine lactones upregulated an uncharacterized gene cluster (bta) in Burkholderia thailandensis E264 to produce an uncharacterized polar antibiotic. The antibiotic is identified as a mixture of four bactobolins. Annotation of the bta cluster allows us to propose a biosynthetic scheme for bactobolin and reveals unusual enzymatic reactions for further study.
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