4.8 Article

A Simple and Efficient Approach to the Synthesis of 2-Phenylquinazolines via sp3 C-H Functionalization

Journal

ORGANIC LETTERS
Volume 12, Issue 12, Pages 2841-2843

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol100954x

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Funding

  1. Natural Science Foundation of China [20932002, 20972144, 20628202, 20772188, 90813008]
  2. Chinese Academy of Sciences
  3. USTC

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A facile and novel approach to the synthesis of 2-phenylquinazolines was developed via a tandem reaction following sp(3) C-H functionalization. Twenty-five examples of 2-phenylquinazolines were obtained from easily available 2-aminobenzophenones and benzylic amines with good to excellent yields.

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