Journal
ORGANIC LETTERS
Volume 12, Issue 2, Pages 324-327Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol9026599
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1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) has been found to catalyze the amidation of acyl Imidazoles. The rate acceleration is especially evident with traditionally unreactive, electron-deficient anilines. DBU is readily available and offers safety and cost advantages over more commonly employed catalysts such as 1-hydroxybenzotriazole.
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