Journal
ORGANIC LETTERS
Volume 12, Issue 6, Pages 1208-1211Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol902974j
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Funding
- NSFC [30830115, 20802082]
- NSF of Yunan province [2008GA031]
- 973 Program [2009CB522300, 2009CB940900]
- Yong Academic and Technical Leader Rising Foundation of Yunnan Province [2006PY01-47]
- CAS
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A new cytotoxic triterpenold, schinalactone A (1), together with two new biogenetically related compounds, schinalactones B (2) and C (3), has been isolated from the roots and stems of Schisandra sphenanthera. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1 and 2 showed significant cytotoxicity against PANC-1 cell lines with IC50 values of 5.9 and 4.1 mu M, respectively, A plausible biosynthetic pathway of 1 was also postulated.
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