Journal
ORGANIC LETTERS
Volume 12, Issue 13, Pages 2896-2899Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol100822k
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Funding
- NSFC [20802074]
- National Basic Research Program of China (973 Program) [2010CB833300]
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A highly diastereo- and enantioselective Michael addition reaction with respect to prochiral 3-substituted oxindoles and maleimides by a chiral bifunctional thiourea tertiary amine catalyst was investigated for the first time. The corresponding adducts, containing a quaternary center at the C3-position of the oxindole as well as a vicinal tertiary center, were generally obtained in good to high yields (up to 92%) with high to excellent diastereo- (up to 99:1 dr) and enantioselectivities (up to 99% ee).
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