4.8 Article

Diastereoselective Synthesis of 6-Trifluoromethyl-5,6-dihydropyrans via Phosphine-Catalyzed [4+2] Annulation of α-Benzylallenoates with Ketones

Journal

ORGANIC LETTERS
Volume 12, Issue 18, Pages 4168-4171

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol101762z

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Funding

  1. National Natural Science Foundation of China [20872143, 20932008]
  2. Ministry of Science and Technology of China [2009ZX-5909501-018]
  3. Chinese Academy of Sciences

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The highly diastereoselective synthesis of 6-trifluoromethyl-5,6-dihydropyrans was realized by the phosphine-catalyzed [4 + 2] annulation of ethyl alpha-benzylallenoates and trifluoromethyl ketones.

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