Journal
ORGANIC LETTERS
Volume 12, Issue 2, Pages 316-319Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol902651j
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- Thomas F. and Kate Miller Jeffress Memorial Trust
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General reaction conditions for the Pd-catalyzed decarboxylative benzylation of benzyl diphenylglycinate Imines are described. The overall procedure requires a simple catalyst/ligand combination to form a new CSp(3)-CSp(3) bond. Microwave irradiation greatly accelerated the transformation. Moreover, various heteroaromatic moieties are tolerated in both the imine and ester components.
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