4.8 Article

Direct Synthesis of Arylketones by Nickel-Catalyzed Addition of Arylboronic Acids to Nitriles

Journal

ORGANIC LETTERS
Volume 12, Issue 8, Pages 1736-1739

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol1003252

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Funding

  1. National Science Council of the Republic of China [NSC-96-2113-M-007-020MY3]

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A convenient and efficient method for the synthesis of various arylketones by nickel-catalyzed addition of arylboronic acids to nitriles is described. A catalytic cycle involving Ni(II) species as the catalytic intermediates is proposed to account for the present catalytic reaction.

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