Journal
ORGANIC LETTERS
Volume 12, Issue 12, Pages 2682-2685Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol1007795
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Funding
- Ministry of Education in Singapore [ARC12/07, T206B3225]
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A highly enantio- and diastereoselective organocatalytic domino Michael Henry process for the preparation of synthetically unique and medicinally important bicyclo[3.2.1]octane derivatives with four stereogenic centers including two quaternary stereocenters has been developed. Theoretical OFT calculations on the transition states have been carried out to reveal origins of the excellent stereoselectivities. A novel dual model was thus proposed.
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