Journal
ORGANIC LETTERS
Volume 12, Issue 22, Pages 5158-5161Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol102162d
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Funding
- Australian Postgraduate Award
- UQ International Postgraduate Student Award
- CONICYT, Chile [PSD32]
- Ministry of Education of Chile [002251/07]
- Universidad de La Frontera [002251/07]
- Institute for Molecular Bioscience, The University of Queensland
- Australian Research Council [LP0989954]
- Australian Research Council [LP0989954] Funding Source: Australian Research Council
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Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0423) isolated from beach sand off Heron Island, Australia, yielded three new members of the rare pyrroloterpene biosynthetic structure class. Identified by detailed spectroscopic analysis as the first reported examples of naturally occurring 2-nitropyrroles, heronapyrroles A-C (1-3) displayed promising biological activity-with low to submicromolar IC50 activity against Gram-positive bacteria but no cytotoxicity toward mammalian cell lines.
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