4.8 Article

Pd(II)-Catalyzed Synthesis of Carbolines by Iminoannulation of Internal Alkynes via Direct C-H Bond Cleavage Using Dioxygen as Oxidant

Journal

ORGANIC LETTERS
Volume 12, Issue 7, Pages 1540-1543

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol100272s

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Funding

  1. Peking University
  2. National Science Foundation of China [20702002, 20872003]
  3. National Basic Research Program of China (973 Program) [2009CB825300]

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A palladium-catalyzed iminoannulation of Internal alkynes via direct C-H bond cleavage was developed. Dioxygen was employed as a clean oxidant In this kind of catalysis. Carbolines were synthesized from tert-butylimines of N-substituted Indole-2-carboxaldehydes or indole-3-carboxaldehydes.

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