4.8 Article

Improved Synthesis of the Two-Photon Caging Group 3-Nitro-2-Ethyldibenzofuran and Its Application to a Caged Thymidine Phosphoramidite

Journal

ORGANIC LETTERS
Volume 12, Issue 5, Pages 916-919

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol902807q

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Funding

  1. National Institutes of Health [R01GM079114]
  2. Beckman Young Investigator Award
  3. Cottrell Scholar Award
  4. NSF
  5. TEVA USA Scholars Grant

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A new and efficient route to the recently reported 3-nitro-2-ethyldibenzofuran caging group was developed. Furthermore, its installation on a thymidine phosphoramidite is described. This caging group is efficiently removed through light-irradiation at 365 rim.

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