The Raputindoles: Novel Cyclopentyl Bisindole Alkaloids from Raputia simulans

A novel class of bisindole alkaloids is established by the isolation and structural determination of raputindoles A-D (1-4) from the Amazonian plant Raputia simulans Kallunki (Rutaceae). Complete spectroscopic characterization was accomplished by means of NMR spectroscopy and APCI (+) HRMS. Raputindoles A-D possess a cyclopentyl moiety fused on the benzene part of the indole ring, originating from the combination of prenylated indole monomers.