4.8 Article

Asymmetric Synthesis of Indolines by Catalytic Enantioselective Reduction of 3H-Indoles

Journal

ORGANIC LETTERS
Volume 12, Issue 20, Pages 4604-4607

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol1019234

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Funding

  1. Evonik-Degussa GmbH
  2. DFG

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A highly enantioselective metal-free reduction of 3H-indoles has been developed. This Bronsted acid catalyzed transfer hydrogenation of indole derivatives with Hantzsch dihydropyridine as the hydrogen source constitutes an efficient method for the synthesis of various optically active indolines with high enantioselectivities

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