4.8 Article

Unprecedented Cu(I)-Catalyzed Microwave-Assisted Three-Component Coupling of a Ketone, an Alkyne, and a Primary Amine

Journal

ORGANIC LETTERS
Volume 12, Issue 11, Pages 2638-2641

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol1008312

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Funding

  1. Katholieke Universiteit Leuven
  2. FWO (Fund for Scientific Research, Flanders, Belgium)

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An efficient, microwave-assisted Cu(I)-catalyzed one-pot coupling of a ketone, an alkyne, and a primary amine (KA(2) coupling) is described, giving access to secondary propargylamines.

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