Journal
ORGANIC LETTERS
Volume 12, Issue 15, Pages 3567-3569Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol101450u
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Funding
- EPFL
- Swiss National Science Foundation [200021_126498]
- Swiss National Science Foundation (SNF) [200021_126498] Funding Source: Swiss National Science Foundation (SNF)
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A simple and straightforward method has been developed for the direct carboxylation of aromatic heterocylces such as oxazoles, thiazoles, and oxadiazoles using CO(2) as the C1 source. The reactions require no metal catalyst and only Cs(2)CO(3) as the base. A good functional group tolerance is achieved.
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