4.8 Article

Multicomponent Reaction Discovery: Three-Component Synthesis of Spirooxindoles

Journal

ORGANIC LETTERS
Volume 12, Issue 3, Pages 572-575

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol902764k

Keywords

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Funding

  1. NIGMS [P50-GM067041]
  2. Merck
  3. NMR [CHE-0619339]
  4. MS [CHE-0443618]
  5. NSF

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The Lewis acid-catalyzed, three-component reaction of isatin and two 1,3-dicarbonyl compounds is reported. Reactions proceed with high efficiency under mild reaction conditions and with good functional group tolerance to afford spirooxindole pyranochromenedione derivatives.

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