Journal
ORGANIC LETTERS
Volume 12, Issue 22, Pages 5246-5249Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol102289g
Keywords
-
Categories
Funding
- French Research Ministry
- Agence Nationale pour la Recherche [ANR-07-CP2D-06]
- Universite Paul Cezanne
- CNRS [UMR 6263]
Ask authors/readers for more resources
The first organocatalytic enantio- and diastereoselective conjugate addition of alpha-ketoamides to nitroalkenes has been achieved using a bifunctional amino thiourea catalyst. In this new approach, the substrate amide proton plays a critical role in the formation of the Michael anti-adducts in high yields and high stereoselectivities. To illustrate the high synthetic potential of this methodology, the diastereo- and enantioselective synthesis of a hexasubstituted cyclohexane via a Michael-Michael-Henry cascade reaction is described.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available