4.8 Article

Total Synthesis of (±)-Galanthamine via a C3-Selective Stille Coupling and IMDA Cycloaddition Cascade of 3,5-Dibromo-2-pyrone

Journal

ORGANIC LETTERS
Volume 12, Issue 9, Pages 2016-2018

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol100617u

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Funding

  1. National Research Foundation [KRF-2008-313-C00467, 2009-0080752]
  2. BK21
  3. National Research Foundation of Korea [2008-313-C00467, 2009-0080752] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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A new efficient synthetic route to (+/-)-galanthamine was devised by using a tandem C3-selective Stifle coupling-IMDA cascade of 3,5-dibromo-2-pyrone as a key strategy.

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