4.8 Article

Stereoselective Synthesis of Substituted Tetrahydropyrans via Domino Olefin Cross-Metathesis/Intramolecular Oxa-Conjugate Cyclization

Journal

ORGANIC LETTERS
Volume 12, Issue 7, Pages 1636-1639

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol100431m

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Funding

  1. MEXT, Japan

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A novel strategy for the stereoselective synthesis of substituted tetra hydropyrans has been developed on the basis of a domino olefin cross-metathesis/intramolecular oxa-conjugate cyclization catalyzed by the Hoveyda-Grubbs second-generation catalyst.

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