Journal
ORGANIC LETTERS
Volume 12, Issue 8, Pages 1716-1719Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol100260z
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Funding
- NSERC-Canada
- Merck Frosst Canada Ltd.
- Michael Smith Foundation for Health Research
- NSERC CGS
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A concise, stereoselective synthesis of functionalized tetrahydrofuranols has been developed that involves heating readily available chloropolyols in water. These reactions are operationally straightforward and chemoselective for the formation of tetrahydrofurans, obviating the need for complicated protecting group strategies. The efficiency of this process is demonstrated in a short asymmetric synthesis of the natural product (+)-goniothalesdiol.
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