Journal
ORGANIC LETTERS
Volume 12, Issue 18, Pages 4130-4133Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol1017245
Keywords
-
Categories
Funding
- University of Bologna, MIUR (Rome)
- CNR (Rome)
- COST Action CM0603
- CNR/RAS
Ask authors/readers for more resources
Addition of millimolar amounts of a weak base (pyridines) dramatically accelerates the reaction with peroxyl radicals of two biologically relevant uracil derivatives, 5-hydroxyuracil (HU) and 5-hydroxy-6-methyluracil (HMU). This is due to the formation of small amounts of the deprotonated form (pK(a) = 8.1-8.5 in water), which reacts with peroxyl radicals much faster than the parent undissociated form, via formal H-atom transfer from the OH in the 5 position.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available