4.8 Article

N-Heterocyclic Carbene-Catalyzed Intramolecular Aldehyde-Nitrile Cross Coupling: An Easy Access to 3-Aminochromones

Journal

ORGANIC LETTERS
Volume 12, Issue 2, Pages 352-355

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol9026232

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Funding

  1. Nanyang Technological University [RG50/08]
  2. Ministry of Health, Singapore [NMRC/HINIR/001/2009]

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An immense effort has been made to develop an efficient strategy for the carbon-carbon bond formation between aldehyde and nitrile intramolecularly using an N-heterocyclic carbene catalyst to derive 3-aminochromone derivatives in good to excellent yields (80-95%).

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