Journal
ORGANIC LETTERS
Volume 12, Issue 21, Pages 4820-4823Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol1019794
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Funding
- NIH [GM067201]
- A*STAR
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To explore a new modular metal ion sensor design strategy, fluorophores and ligands were incorporated into short DNA-like oligomers. Compound 1 was found to function as a selective sensor for Ag+ in aqueous buffer, where low micromolar concentrations of Ag+ induce a red-shifted, turn-on fluorescence signal. Experiments with HeLa cells show that 1 can penetrate cells and yield a signal for intracellular Ag+ This suggests a broadly applicable approach to developing sensors for a wide variety of cations.
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