Journal
ORGANIC LETTERS
Volume 12, Issue 12, Pages 2690-2693Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol1004356
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1-Aryltetrahydroisoquinolines (1-arylTHIQs) are Important structural motifs in many alkaloids and biologically active compounds. Ligand 2a promotes the enantioselective addition of arylzinc reagents to 3,4-dihydroisoquinoline N-oxide to yield (S)-1-arylTHIQs in 97-99% ee. Pinacol arylboronic esters are the optimal precursors for the arylzinc reagents. This method is applied to the enantioselective synthesis of Solifenacin.
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