4.8 Article

Ambient Temperature Nitrogen-Directed Difluoroalkynylborane Carboni-Lindsey Cycloaddition Reactions

Journal

ORGANIC LETTERS
Volume 12, Issue 1, Pages 160-163

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol902573x

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Funding

  1. EPSRC [EP/D03213X/1]
  2. Engineering and Physical Sciences Research Council [EP/D03213X/1] Funding Source: researchfish

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The in situ generation of alkynyldifluoroboranes in the presence of N-heterocycle substituted tetrazines provides a convenient and direct method for the synthesis of pyridazine difluoroboranes. The reactions proceed In 10 min under ambient conditions and provide the opportunity to assemble unsymmetrical products with complete regiocontrol.

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