Journal
ORGANIC LETTERS
Volume 12, Issue 21, Pages 4952-4955Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol102087r
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Funding
- National Institutes of Health, National Institute of General Medical Sciences [GM087620]
- Eli Lilly
- Skaggs Institute for Chemical Biology
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An efficient room-temperature method for the synthesis of 1-sulfonyl-1,2,3-triazoles from in situ generated copper(I) acetylides and sulfonyl azides is described. The copper(I) thiophene-2-carboxylate (CuTC) catalyst produces the title compounds under both nonbasic anhydrous and aqueous conditions in good yields.
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