Journal
ORGANIC LETTERS
Volume 12, Issue 14, Pages 3242-3245Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol1011949
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Funding
- National Institutes of Health [GM-64444, 1P50 GM-086145]
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An efficient two-component palladium-catalyzed arylation/cyclization cascade approach toward a variety of N-fused pyrroloheterocycles has been developed. This transformation proceeds via the palladium-catalyzed coupling of aryl halides with propargylic esters or ethers followed by the 5-endo-dig cyclization leading to highly functionalized pyrroloheterocycles in good to excellent yield.
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