Journal
ORGANIC LETTERS
Volume 12, Issue 7, Pages 1416-1419Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol902819j
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Funding
- National Cancer Institute [CA17625-32]
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A new versatile synthetic methodology for the synthesis of enantiomerically pure natural phenanthroindolizidines and phenanthroquinolizidines has been established and described. Natural products R-antofine and R-cryptopleurine, as well as a novel E-ring expanded analogue 13c (E7), 12-oxo-S-antofine (17), and 12N-methyl-12-aza-S-antofine (18) were synthesized with the new method. This strategy will greatly facilitate future SAR studies on the natural alkaloids with E-ring variations.
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