4.8 Article

Rh2(OAc)4-AgOTf Cooperative Catalysis in Cyclization/Three-Component Reactions for Concise Synthesis of 1,2-Dihydroisoquinolines

Journal

ORGANIC LETTERS
Volume 12, Issue 4, Pages 652-655

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol902409u

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Funding

  1. National Natural Science Foundation of China [20932003, 20772033]
  2. Science and Technology Commission of Shanghai Municipality [09JC1404901, 07dz22005]

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Dirhodium acetate and silver triflate cooperatively catalyzed tandem cyclization/three-component reactions of 2-alkynylarylaldimines with diazo compounds and water or alcohols are reported to afford 1,2-dihydroisoquinolines bearing alpha-hydroxyl-beta-amino carboxylate skeleton in high yield.

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