4.8 Article

One-Pot Three-Step Synthesis of 1,2,3-Triazoles by Copper-Catalyzed Cycloaddition of Azides with Alkynes formed by a Sonogashira Cross-Coupling and Desilylation

Journal

ORGANIC LETTERS
Volume 12, Issue 21, Pages 4936-4939

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol1022036

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Funding

  1. National Cancer Institute of the US National Institutes of Health [RO1 CA88986]

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A microwave-assisted, one-pot, three-step Sonogashira cross-coupling-desilylation-cycloaddition sequence was developed for the convenient preparation of 1,4-disubstituted 1,2,3-triazoles starting from a range of halides, acyl chlorides, ethynyltrimethylsilane, and azides.

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