Journal
ORGANIC LETTERS
Volume 12, Issue 21, Pages 4752-4755Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol101707u
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Funding
- Portuguese Foundation for Science and Technology [PTDC/FIS/73578/2006]
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Bioassay-guided fractionation of the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian coast led to the isolation of a novel family of brominated guanidinium oxazolidinones named synoxazolidinones A and B (1 and 2). The backbone of the compounds contains a 4-oxazolidinone ring rarely seen in natural products. The structure of the compounds was determined by spectroscopic methods. The synoxazolidinones exhibited antibacterial and antifungal activities.
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