4.8 Article

Ruthenium-Catalyzed Tertiary Amine Formation from Nitroarenes and Alcohols

Journal

ORGANIC LETTERS
Volume 12, Issue 21, Pages 4888-4891

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol1020527

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Funding

  1. National Natural Science Foundation of China [20902076]
  2. Xiangtan University [09QDZ12]

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A highly selective ruthenium-catalyzed C-N bond formation was developed by using the hydrogen-borrowing strategy. Various tertiary amines were obtained efficiently from nitroarenes and primary alcohols. The reaction tolerates a wide range of functionalities. A tentative mechanism was proposed for this direct amination reaction of alcohols with nitroarenes.

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