4.8 Article

Simple and Efficient Preparation of 2,5-Disubstituted Oxazoles via a Metal-Free-Catalyzed Cascade Cyclization

Journal

ORGANIC LETTERS
Volume 12, Issue 17, Pages 3902-3905

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol101596s

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Funding

  1. Natural Science Foundation of China [20932002, 20972144, 20628202, 20772188, 90813008]
  2. Chinese Academy of Sciences

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A practical and simple synthesis of 2,5-disubstituted oxazoles was developed via an iodine-catalyzed tandem oxidative cyclization. A wide range of common commercial aromatic aldehydes can be used as reaction substrates, which displayed excellent functional group compatibility in this reaction.

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