4.8 Article

One-Pot Silver-Catalyzed and PIDA-Mediated Sequential Reactions: Synthesis of Polysubstituted Pyrroles Directly from Alkynoates and Amines

Journal

ORGANIC LETTERS
Volume 12, Issue 2, Pages 312-315

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol9026478

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Funding

  1. National Natural Foundation of China [20625205, 20772034, 20932002]
  2. Guangdong Natural Science Foundation [07118070]

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The addition/oxidative cyclization of alkynes with amines in the presence of AgBF4 catalyst and PIDA oxidant leads to polysubstituted pyrroles. The reaction corresponds to the construction of a pyrrole fragment, which also provides a new way to the formation of C-C bonds.

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