4.8 Article

Ruthenium-Catalyzed Tandem Ring-Opening/Ring-Closing/Cross-Metathesis of 1,6-Cyclopropene-ynes and Olefins for the Construction of the 3-Pyrroline Skeleton

Journal

ORGANIC LETTERS
Volume 12, Issue 20, Pages 4462-4465

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol101455c

Keywords

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Funding

  1. Shanghai Municipal Committee of Science and Technology [08d1400100-2]
  2. National Basic Research Program of China [2009CB825300]
  3. National Natural Science Foundation of China [20872162, 20672127, 20732008, 20521002, 20702013]

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Catalyzed by the first-generation Grubbs' ruthenium complex, tandem intramolecular/intermolecular metathesis of 1,6-enynes bearing a cyclopropene ring took place smoothly to produce 3-pyrroline derivatives in satisfactory yields via ring-opening/ring-closing/cross-metathesis processes.

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