Journal
ORGANIC LETTERS
Volume 12, Issue 7, Pages 1588-1591Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol1003143
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Funding
- NSF [CHE-0848410]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0848410] Funding Source: National Science Foundation
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A new class of nonpeptidic alpha-helix mimetics derived from alpha-amino acids and featuring chiral backbones Is described. NMR and circular dichroism spectroscopies, In combination with molecular modeling studies, provide compelling evidence that oligooxopiperazine dimers adopt stable conformations that reproduce the arrangement of i, i+4, and i+7 residues on an alpha-helix.
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