Journal
ORGANIC LETTERS
Volume 12, Issue 12, Pages 2770-2773Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol100849j
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Funding
- Swiss National Science Foundation [200020-113332]
- university of Cambridge (UK)
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The first highly enantioselective and regiodivergent conjugate addition of trialkylaluminium reagents to nitrodienes and nitroenynes is described. By a design of the substrate and a fine-tuning of the reaction conditions, it is possible to selectively form the 1,4- or 1,6-adduct. The same combination of catalyst, copper source, and a ferrocene-based phosphine ligand afforded enantioselectivities up to 95% and 91%, respectively.
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