Journal
ORGANIC LETTERS
Volume 12, Issue 17, Pages 3926-3929Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol101618u
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Funding
- The Hong Kong Research Grants Council [PolyU 5031/09P, SEG_PolyU01]
- The Areas of Excellence Scheme [AoE/P-10-01]
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A Pd-catalyzed protocol for direct C-H bond acylation by cross coupling of aryl ketone oximes and aldehydes using fert-butyl hydroperoxide (TBHP) as oxidant was developed. With oximes as a directing group for the C-H activation, the coupling with aldehydes was achieved with remarkable regioselectivity. The acylation reactions exhibit excellent functional group tolerance, and both aliphatic and heteroaromatic aldehydes can be effectively coupled to the oximes.
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