4.8 Article

Enantioselective α-Amination of 1,3-Dicarbonyl Compounds Using Squaramide Derivatives as Hydrogen Bonding Catalysts

Journal

ORGANIC LETTERS
Volume 12, Issue 9, Pages 2028-2031

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol1005104

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Funding

  1. National Institutes of Health [R01GM069990]
  2. Hong Kong Croucher Foundation

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Catalytic enantioselective alpha-hydrazination of 1,3-dicarbonyl compounds with azodicarboxylates was investigated in the presence of our newly developed hydrogen bonding catalyst, squaramide 3j. High yields and high enantioselectivities were achieved with low catalyst loading under mild conditions.

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