Journal
ORGANIC LETTERS
Volume 12, Issue 12, Pages 2766-2769Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol100857s
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Funding
- National Natural Science Foundation of China [20972101]
- PCSIRTC [IRT0846]
- National Basic Research Program of China (973 Program) [2010CB833300]
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The efficient assembly of hydroindane derivatives incorporating a spirooxindole motif was realized via a new three-component domino reaction of (E)-4-(1-methyl-2-oxoindolin-3-ylidene)-3-oxobutanoates and two molecules of alpha,beta-unsaturated aldehydes under quadruple iminium-enamine-iminium-enamine catalysis. The complex products bearing six contiguous stereogenic centers were obtained in excellent stereoselectivities (96->99% ee, >99% de).
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